Assessing Regular PPI and H2RA Use

Regular use of PPIs or H2RAs was firstly assessed by participants using a touchscreen questionnaire. The participants were asked “Do you regularly take any prescription medications?”. ‘Regularly’ was routinely defined as most days of the week for the last 4 weeks. If participant selected ‘Yes’ or ‘Unsure’, then they would be asked by a trained staff: “In the touch screen you said you are taking regular prescription medications. Can you now tell me what these are?” The recorded types of PPIs included omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole. The kinds of H2RAs included ranitidine, cimetidine, famotidine and nizatidine.

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Yang M., Xia B., Lu Y., He Q., Lin Y., Yue P., Bai B., Dong C., Meng W., Qi J, & Yuan J. (2022). Association Between Regular Use of Gastric Acid Suppressants and Subsequent Risk of Cholelithiasis: A Prospective Cohort Study of 0.47 Million Participants. Frontiers in Pharmacology, 12, 813587.

Publication 2021

Cimetidine Esomeprazole Famotidine Lansoprazole Nizatidine Omeprazole Pantoprazole Ppis Prescription medications Rabeprazole Ranitidine Touch

Corresponding Organization : The Seventh Affiliated Hospital of Sun Yat-sen University

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Variable analysis

independent variables

Regular use of PPIs or H2RAs

dependent variables

Types of PPIs (omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole)
Types of H2RAs (ranitidine, cimetidine, famotidine and nizatidine)

control variables

Participants' self-reported regular use of prescription medications, defined as most days of the week for the last 4 weeks

controls

Positive control: Participants who selected 'Yes' or 'Unsure' to regularly taking prescription medications were asked to provide details on the types of medications they were taking.
Negative control: Not explicitly mentioned.

Annotations

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