Digitalization of Breast Biopsy Slides for Pathology Review

Hematoxylin and eosin (H&E) breast tissue slides were retrieved for biopsy-confirmed BBD patients who gave permission to review their biopsy records (18 (link),20 (link),21 (link)). H&E slides were available for 488 cases and 2124 controls (i.e., full nested case-control study group) for centralized pathology review (5 (link),18 (link),19 (link)). Within this group, a total of 3836 slides were digitized into WSIs at 20× (n=234) or 40× (n=3602) magnification using the Panoramic SCAN 150 (3DHISTECH Ltd, Budapest, Hungary). For women with good quality slides, up to six slides from different tissue blocks were digitized. H&E slides that could not be digitized were due to poor quality, slides too thick to fit into scanner, and plastic mounting covers. Attempts to create new H&E slides were not always possible due to missing (or returned to hospital) blocks, old-style blocks not created using tissue cassettes, or poor-quality blocks.

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Kensler K.H., Liu E.Z., Wetstein S.C., Onken A.M., Luffman C.I., Baker G.M., Collins L.C., Schnitt S.J., Bret-Mounet V.C., Veta M., Pluim J.P., Liu Y., Colditz G.A., Eliassen A.H., Hankinson S.E., Tamimi R.M, & Heng Y.J. (2020). Automated Quantitative Measures of Terminal Duct Lobular Unit Involution and Breast Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(11), 2358-2368.

Publication 2020

Panoramic SCAN 150

Biopsy Breast Eosin Hematoxylin Patients Scan Tissue Women

Corresponding Organization :

Other organizations : Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Harvard University, Eindhoven University of Technology, Dana-Farber Brigham Cancer Center, Brigham and Women's Hospital, University of Massachusetts Amherst, Cornell University

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Variable analysis

independent variables

Hematoxylin and eosin (H&E) breast tissue slides
Magnification of digitized slides (20× or 40×)

dependent variables

Centralized pathology review of H&E slides

control variables

Biopsy-confirmed BBD patients who gave permission to review their biopsy records
Full nested case-control study group of 488 cases and 2124 controls

controls

Positive control: Not specified
Negative control: Not specified

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