All experiments were conducted according to the German Animal Welfare Act and were approved by the State Agency for Nature, Environment and Consumer Protection of North Rhine-Westphalia, Germany (LANUV approval IDs: 87-51.04.2010.A274, 84-02.04.2015.A427, 84-02.04.2016.A135, and 81-02.04.2018.A426). Experiments were performed with 71 adult Fischer rats (>3 month). A total of 70 animals were female and had a weight of (184 ± 14) g, one animal was male and weighed 261 g. Rats were housed in groups of two to five animals under a regular light/dark schedule (12/12 h) with food and water ad libitum.
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