USP14 promotes the proliferation of PCa cells and is closely associated with its progression (Liao et al., 2017 (link)). It can also promote the development of PCa by stabilizing AR protein and ATF2 (activating the transcription factor 2) (Geng et al., 2020 (link); Liao et al., 2017 (link)). USP14 is a novel regulator of AR (Liao et al., 2017 (link)). AR protein is overexpressed in PCa and plays a key role in its growth and progression (Liao et al., 2017 (link)). ATF2, an oncogene of PCa, facilitates the proliferation of PCa cells (Geng et al., 2020 (link)).
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