MR imaging was performed on a whole body 3 T MRI-scanner (GE Discovery, Milwaukee, WI, USA) using a 32-channel head coil. The protocol included a three-dimensional (3D) T1-weighted fast spoiled gradient echo scan (FSPGR; repetition time (TR) = 8.22 ms, echo time (TE) = 3.22 ms, inversion time (TI) = 450 ms, flip angle 12°, 1.0 mm sagittal slices with 0.94 × 0.94 mm2 in-plane resolution) and a 3D fluid-attenuated inversion recovery (FLAIR; TR = 8000 ms; TE = 128 ms; TI = 2343 ms; 1.2 mm sagittal slices; 0.98 × 0.98 mm2 in-plane resolution).
White matter lesions were automatically segmented on the FLAIR image and filled on the 3D-T1 images according to previously published methods.43 (link),44 (link) FSL’s Sienax (fsl.fmrib.ox.ac.uk) was used to obtain volumes of white and grey matter (WMV, GMV) and FIRST was used to obtain total deep grey matter volume, thalamic volume and right and total hippocampal volume. All volumes were normalized for head size.
White matter lesions were automatically segmented on the FLAIR image and filled on the 3D-T1 images according to previously published methods.43 (link),44 (link) FSL’s Sienax (fsl.fmrib.ox.ac.uk) was used to obtain volumes of white and grey matter (WMV, GMV) and FIRST was used to obtain total deep grey matter volume, thalamic volume and right and total hippocampal volume. All volumes were normalized for head size.
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