tBOC-PEG3500-NH2·HCl and mPEG3000-NH2·HCl were ordered from JenKem Technology USA, Inc. (Allen, TX). Acid-terminated PLGA (lactide/glycolide (50:50)) was purchased from DURECT Corporation (Pelham, AL). Cisplatin was purchased from Acros Organics (Fair Lawn, NJ). RAPA was purchased from ChemieTek (Indianapolis, IN). Hexanol, Triton X-100, cyclohexane, p-anisic acid, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC), N-hydroxysuccinimide (NHS), and N,N-diisopropylethylamine (DIPEA) were obtained from Sigma-Aldrich (St. Louis, MO). DOPA was purchased from Avanti Polar Lipids (Alabaster, AL). 3H-Labeled paclitaxel[o-benzamido-3H(N)] and 14C-labeled stearic acid were purchased from Moravek Biochemicals and Radiochemicals (Brea, CA).
Protocol detail
Synthesis and Characterization of PEGylated PLGA Nanoparticles
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tBOC-PEG3500-NH2·HCl
Acid-terminated PLGA (lactide/glycolide (50:50))
Cisplatin
Hexanol
Triton X-100
cyclohexane
p-anisic acid
1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC),
N-hydroxysuccinimide (NHS),
N,N-diisopropylethylamine (DIPEA)
Alabaster
Carbodiimide
Cisplatin
Cyclohexane
Dopa
Hexanol
Lactide
Lipids
N hydroxysuccinimide
P anisic acid
Paclitaxel
Plga
Radiochemicals
Stearic acid
Triton x 100
Corresponding Organization : University of North Carolina at Chapel Hill
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Protocol cited in 4 other protocols
Variable analysis
independent variables
- TBOC-PEG3500-NH2·HCl
- MPEG3000-NH2·HCl
- Acid-terminated PLGA (lactide/glycolide (50:50))
- Cisplatin
- Hexanol
- Triton X-100
- Cyclohexane
- P-anisic acid
- 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC)
- N-hydroxysuccinimide (NHS)
- N,N-diisopropylethylamine (DIPEA)
- Not explicitly mentioned
- 3H-Labeled paclitaxel[o-benzamido-3H(N)]
- 14C-labeled stearic acid
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