Neuroprotective Effects of LIF in Stroke

All animals were treated prophylactically with ketoprofen (10 mg/kg s.c.) and atropine (0.25 mg/kg s.c.) with two additional doses of ketoprofen at 24 and 48 h post-MCAO. Recombinant human LIF (ProSpec, Ness Ziona, Israel) (125 μg/kg) or PBS (pH 7.4) was administered intravenously at 6, 24, and 48 h post-MCAO as previously described [34 (link), 35 (link)]. Animals were randomly assigned to treatment groups, and all lab personnel administering drugs were blinded to treatments.

Free full text: Click here

Davis S.M., Collier L.A., Messmer S.J, & Pennypacker K.R. (2020). The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents. Oxidative Medicine and Cellular Longevity, 2020, 8880244.

Publication 2020

Recombinant human LIF

Animals Atropine Drugs Human Ketoprofen Ness Prospec

Corresponding Organization : University of Kentucky

Top 5 similar protocols

Variable analysis

independent variables

Recombinant human LIF (ProSpec, Ness Ziona, Israel) (125 μg/kg)
PBS (pH 7.4)

dependent variables

Unspecified

control variables

Ketoprofen (10 mg/kg s.c.)
Atropine (0.25 mg/kg s.c.)

controls

Positive control: Recombinant human LIF (ProSpec, Ness Ziona, Israel) (125 μg/kg)
Negative control: PBS (pH 7.4)

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!