National Survey of Breast Cancer ET Adherence

This study was a national population-based survey of women with stages I–III breast cancer prescribed ET in Ireland. Eligible women were identified from the records of the population-based National Cancer Registry Ireland and were: (i) aged ≥ 18 years; (ii) had a diagnosis of stages I–III, estrogen (ER) or progesterone (PR) receptor positive breast cancer during 01/07/2009-–30/06/2014; (iii) received tumour-directed surgery; (iv) were prescribed adjuvant ET (selective estrogen receptor modulator, SERM; aromatase inhibitor, AI) within 1 year of breast cancer diagnosis and up to 5 years and were (v) alive. Women were excluded if they had previously been diagnosed with another invasive cancer other than non-melanoma skin cancer (N = 2890 eligible women). GPs (N = 656) screened women for any medical reasons that they should not be invited to take part in the study (e.g. cancer recurrence, metastatic disease, palliative care, deceased) and 355 (12%) were considered to be ineligible. In total, 2535 eligible women were invited, by post, to self-complete a questionnaire measuring; (i) socio-demographics; (ii) modifiable determinants of ET non-adherence and; (iii) non-adherence (Fig. 1). Ethical approval was granted by the Irish College of General Practitioners. Informed consent was obtained from all individual participants included in the study.Fig. 1

Number of participants at each stage of the study

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Cahir C., Bennett K., Dombrowski S.U., Kelly C.M., Wells M., Watson E, & Sharp L. (2023). Informing interventions to improve uptake of adjuvant endocrine therapy in women with breast cancer: a theoretical-based examination of modifiable influences on non-adherence. Supportive Care in Cancer, 31(3), 200.

Publication 2023

Adjuvant Aromatase inhibitor Breast cancer Breast cancer diagnosis Cancer Estrogen General practitioners Melanoma skin cancer Metastatic disease Palliative care Progesterone receptor Recurrence Serm Surgery Tumour Women

Corresponding Organization :

Other organizations : University of New Brunswick, Mater Misericordiae University Hospital, Imperial College Healthcare NHS Trust, Imperial College London, Oxford Brookes University, Newcastle University

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Socio-demographics
Modifiable determinants of ET non-adherence
Non-adherence

control variables

None explicitly mentioned

controls

No positive or negative controls were mentioned in the input protocol.

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