Cohort Study of Acute Spontaneous ICH

This real-world, retrospective cohort study was conducted of patients with first-ever acute spontaneous ICH admitted to the Affiliated Hospital of Jiujiang University (Jiujiang, China) diagnosed via head computed tomography (CT) scans from January 2021 to May 2022. All patients were hospitalized within 24 h after stroke, and their hematomas were received non-operative treatment. The exclusion criteria were: (1) less than 18 years old; (2) surgical treatment indicated; (3) ICH resulting from TBI, hemorrhagic transformation of cerebral infarction, intracranial aneurysm, intracranial tumors, arteriovenous malformation, venous sinus thrombosis, or moyamoya disease; (4) pre-ICH modified Rankin scale (mRS) ≥ 2; and (5) other specific conditions, such as severe infections within recent a month, known malignancies, and autoimmune diseases. At the same time, a group of healthy volunteers matched in age and gender were selected as controls. The control group underwent routine laboratory tests, and had no history of surgery and other diseases such as hypertension, diabetes mellitus, malignancies, and stroke. This study was approved by the Institutional Review Boards at Affiliated Hospital of Jiujiang University (Grant No. IRB2022-JJU-032-21). The written informed consent for participating was signed by patients or their immediate family members and controls themselves.

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Wu M., Chen K., Jiang M., Xie F., Cao X., Chen L., Chen Z, & Yin X. (2023). High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage. Frontiers in Aging Neuroscience, 15, 1103278.

Publication 2023

Arteriovenous malformation Autoimmune diseases Cerebral hemorrhagic Computed tomography Diabetes mellitus Family members Gender Head Healthy volunteers Hematomas Hypertension Ich 2 Infarction Infections Institutional review boards Intracranial aneurysm Intracranial tumors Malignancies Moyamoya disease Patients Scans Sinus Sinus thrombosis Stroke Surgery Venous Venous thrombosis

Corresponding Organization : Jiujiang University

Other organizations : Huazhong University of Science and Technology, Wuhan No.1 Hospital

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Variable analysis

independent variables

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dependent variables

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control variables

Gender

controls

Positive, Healthy volunteers matched in age and gender to the patient group
Negative, None explicitly mentioned

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