Biotin and Diet Therapy for Acute Decompensation

Treatment including oral biotin and diet adjustment was commenced immediately after confirming the diagnosis. For patients during acute decompensation, the initial therapy included a low-protein diet, supplementation of biotin as well as L-carnitine, and intravenous fluid therapy with glucose as well as electrolytes. Then the treatment was adjusted according to their response to biotin and other personal condition. The recommended dosage of lifelong administered biotin was 10–40 mg/day [12 (link)].

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Ling S., Qiu W., Zhang H., Liang L., Lu D., Chen T., Zhan X., Wang Y., Gu X, & Han L. (2023). Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency. Orphanet Journal of Rare Diseases, 18, 48.

Publication 2023

Biotin Diagnosis Diet Electrolytes Fluid therapy Glucose L carnitine Low protein diet Patients

Corresponding Organization :

Other organizations : XinHua Hospital

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Variable analysis

independent variables

Treatment including oral biotin
Diet adjustment

dependent variables

Patient response to biotin and other personal condition

control variables

Not explicitly mentioned

controls

No positive or negative controls were explicitly mentioned in the provided information.

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