Example 9
To evaluate whether ebselen has potential as an anti-muscle-wasting compound in human skeletal myotubes, differentiating human primary myoblasts were treated with dexamethasone in the presence and absence of ebselen. As a result, it was confirmed that treatment with dexamethasone reduced both the myotube diameter and the proportion of large diameter myotubes but cotreatment with ebselen inhibited the effect of dexamethasone (
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