An observational analytic study with a case-control design was conducted at outpatient clinics and inpatient wards in the clinical settings of Poltava State Medical University, Ukraine, from August 2020 through February 2021. Written informed consent was obtained from all recruited patients. The study was approved by the local Ethics Committee of Poltava State Medical University, Ukraine.
The study population consisted of Ukrainian COVID-19 patients who had resided in the Poltava region (central part of Ukraine). The inclusion criteria for the study group were subjects with clinical signs and symptoms of COVID-19: i) endotracheal intubation, ii) CPAP/BiPAP ventilation, iii) oxygen therapy, iv) hospitalized without oxygen therapy, v) not hospitalized, and positive results of SARS-CoV-2 PCR tests in nasopharyngeal swabs (14 (link)).
All COVID-19 patients were divided into three clinical groups in accordance with oxygen requirement: group 1 – patients without oxygen therapy (n=62), group 2 – patients with non-invasive oxygen therapy (n=92), group 3 – patients with lung ventilation (invasive oxygen therapy) including 8 patients who died (n=35). We allocated such groups in order to be able to compare our data with previously published results on the gene polymorphisms associations with COVID-19 severity. The control group comprised 92 healthy persons, without a history of fever or respiratory symptoms who had a negative SARS-CoV-2 IgA+IgM+IgG serology and lived in Central Ukraine.
The study population consisted of Ukrainian COVID-19 patients who had resided in the Poltava region (central part of Ukraine). The inclusion criteria for the study group were subjects with clinical signs and symptoms of COVID-19: i) endotracheal intubation, ii) CPAP/BiPAP ventilation, iii) oxygen therapy, iv) hospitalized without oxygen therapy, v) not hospitalized, and positive results of SARS-CoV-2 PCR tests in nasopharyngeal swabs (14 (link)).
All COVID-19 patients were divided into three clinical groups in accordance with oxygen requirement: group 1 – patients without oxygen therapy (n=62), group 2 – patients with non-invasive oxygen therapy (n=92), group 3 – patients with lung ventilation (invasive oxygen therapy) including 8 patients who died (n=35). We allocated such groups in order to be able to compare our data with previously published results on the gene polymorphisms associations with COVID-19 severity. The control group comprised 92 healthy persons, without a history of fever or respiratory symptoms who had a negative SARS-CoV-2 IgA+IgM+IgG serology and lived in Central Ukraine.
