The Institutional Animal Care and Use Committee approved this study. Fourteen 3-months old female domestic pigs were randomized in two groups (n=7 each): Control (Lean) pigs were fed standard chow (13% protein, 2% fat, 6% fiber, Purina Animal Nutrition LLC, MN), and obese with a high-fat/high-fructose diet fed ad libitum (5B4L, protein 16.1%, ether extract fat 43.0%, and carbohydrates 40.8%, Purina Test Diet, Richmond, Indiana), for a total of 16 weeks, with free access to water. At 8, 12, and 16 weeks, subcutaneous abdominal adipose tissue biopsies and fasting blood samples were collected under anesthesia and sterile conditions in all pigs. At 16 weeks, the pigs were studied in-vivo with magnetic resonance imaging (MRI, for myocardial oxygenation) followed by multi-detector computed-tomography (MDCT, for cardiac structure, function, and myocardial perfusion) 2 days later. Three days following the completion of in-vivo studies, pigs were euthanized with pentobesearbital-sodium (100mg/kg IV, Sleepaway®, Fort Dodge Laboratories, Fort Dodge, Iowa). Terminal pericardial and subcutaneous abdominal adipose tissue biopsies were collected and tissue studies performed for assessments of fat inflammation and remodeling.