were procured and used without any further purification. All reactions
were performed in oven-dried glassware. Epoxide (2R,3S)-3-(N-Boc-amino)-1-oxirane-4-phenylbutane
(CAS no. 98760-08-8) was purchased from GLR Innovation (New Delhi,
India), and aromatic amines were purchased from AVRA Synthesis Pvt.
Ltd. (Hyderabad, India). Nitromethane (AR grade) was purchased from
Spectrochem (Mumbai, India), and ethanol (absolute) was purchased
from Changshu Hongsheng Fine Chemical Co., Ltd. (Jiangsu, China).
The reactions were carried out in a “Start Synth Microwave
Synthesis Labstation” microwave for organic synthesis. The
melting point of the isolated compounds was measured in a “BUCHI
Labortechnik AG CH-9230”. The progress of reactions was examined
by using thin-layer chromatography (TLC). Nuclear magnetic resonance
(NMR) spectra were obtained using a JEOL ECX-400P NMR spectrometer.
Chemical shifts were given in parts per million (ppm) downfield from
an internal standard, tetramethylsilane (TMS). The molecular weight
of all newly synthesized compounds was recorded at a high-resolution
Biosystems Q-Star Elite time-of-flight electrospray mass spectrometer.