Hydrogel nanoparticles, poly(N-isopropylacrylamide-co-acrylic acid) (poly(NIPAm-co-AAc)), were synthesized by precipitation polymerization(32 ) and covalently functionalized with amino-containing dyes using amidation chemistry.(33 ) Zero-length cross-linking amidation strategies were performed in water or organic solvents on the basis of the hydrophilic/hydrophobic properties of the dyes. Amine-containing hydrogel nanoparticles, poly(NIPAm-co-AA), were created by precipitation polymerization and covalently functionalized with Cibacron Blue F3GA (CB) dye by nucleophilic substitution of the amine groups in the nanoparticles and a chloride atom in the CB dye. An outer shell containing vinylsulfonic acid (VSA) copolymer was created on the dye-functionalized particles by a second polymerization reaction as described below.
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Dye-Functionalized Hydrogel Nanoparticles
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Acrylic acid
Amine
Chloride
Cibacron blue f3ga
Hydrogel
N isopropylacrylamide
Poly
Poly nipam
Polymerization
Solvents
Vinylsulfonic acid
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Variable analysis
independent variables
- Polymerization conditions (precipitation polymerization)
- Covalent functionalization with amino-containing dyes using amidation chemistry
- Zero-length cross-linking amidation strategies in water or organic solvents
- Covalent functionalization of amine-containing hydrogel nanoparticles (poly(NIPAm-co-AA)) with Cibacron Blue F3GA (CB) dye by nucleophilic substitution
- Second polymerization reaction to create an outer shell containing vinylsulfonic acid (VSA) copolymer on the dye-functionalized particles
- Properties of the hydrogel nanoparticles (not explicitly mentioned)
- Hydrophilic/hydrophobic properties of the dyes
- Positive control: Not mentioned
- Negative control: Not mentioned
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