Dynamic [18F]florbetapir PET in Alzheimer's Disease

Four cognitively normal (CN), Aβ-negative subjects and five AD dementia
(Aβ-positive) patients underwent repeated dynamic
[¹⁸F]florbetapir PET scans (average interval: 4.5 ± 3.0 weeks)
with arterial blood sampling using a Philips Ingenuity TF PET/CT (Philips
Medical Systems, Best, the Netherlands). Prior to the start of a 90 minutes
dynamic PET scan, a low-dose CT was acquired. PET images were reconstructed
into 22 frames using the BLOB (rotationally symmetric volume elements)
ordered-subsets time of flight (BLOB-OS-TF) reconstruction algorithm, with
the vendors’ default settings.^{24 (link)} T1-weighted MRI scans were acquired on either a Signa HDxt MRI
(General Electric, Milwaukee, WI) or an Ingenuity TF PET/MR (Philips Medical
Systems, Cleveland, OH) scanner.¹⁹

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Heeman F., Visser D., Yaqub M., Verfaillie S., Timmers T., Pijnenburg Y.A., van der Flier W.M., van Berckel B.N., Boellaard R., Lammertsma A.A, & Golla S.S. (2022). Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals. Journal of Cerebral Blood Flow & Metabolism, 43(3), 369-378.

Publication 2022

Ingenuity TF PET/CT Signa HDxt MRI Ingenuity TF PET/MR

Arterial Dementia Electric Florbetapir Frames Mri scans Patients Pet ct Pet scan Reconstruction

Corresponding Organization : Vrije Universiteit Amsterdam

Other organizations : University of Amsterdam

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Variable analysis

independent variables

Aβ-negative subjects
AD dementia (Aβ-positive) patients

dependent variables

Dynamic [18F]florbetapir PET scans

control variables

Cognitive normality (CN) of subjects
Arterial blood sampling
Philips Ingenuity TF PET/CT scanner
BLOB-OS-TF reconstruction algorithm
T1-weighted MRI scans (Signa HDxt MRI or Ingenuity TF PET/MR scanner)

controls

Cognitively normal (CN), Aβ-negative subjects as a negative control

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