Acquired LC-MS and GC-MS data were processed using the Thermo Scientific TraceFinder 5.0 software. Targeted metabolites were identified by matching one target and at least one confirming ion and retention time (GC-MS) or accurate mass and retention times (LC-MS) to the University of Iowa Metabolomics Core Facility’s in-house library of confirmed standards. After peak area integration by TraceFinder, NOREVA software was applied for signal drift correction on a metabolite-to-metabolite basis using the pooled QC sample that had been analyzed throughout the instrument run (16 (link)). Within individual samples, Post-NOREVA metabolite levels were divided by the total metabolite load (sum of all metabolite values) to equally weight individual metabolites for comparison across samples.