Preoperative Blood Cell Profiles in GBM

A complete blood count is routinely taken from each patient within 1–3 days prior to surgical intervention and automatically analyzed by ADVIA 2120 hematology system or Sysmex XN hematology analyzer. These laboratory values were obtained at constant time points and enabled us to link them to the patients' overall survival patterns with less bias. Pre-operative RBCs parameters examined included: hemoglobin, RBCs count, hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and RDW. Since the majority of patients were treated with steroids following hospital admission, and it has been well-established in the literature that steroids treatment can distort WBC and neutrophils count (29 (link)), WBC differential and related calculated ratios (e.g., neutrophil-lymphocytes ratio) were not addressed in this study. However, their effect on GBM survival has been addressed in recent years (30 (link)–33 (link)).

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Kaisman-Elbaz T., Elbaz Y., Merkin V., Dym L., Noy A., Atar-Vardi M., Bari R., Turiel S., Alt A., Zamed T., Eskira Y., Lavrenkov K., Kezerle Y., Dyomin V, & Melamed I. (2020). Hemoglobin Levels and Red Blood Cells Distribution Width Highlights Glioblastoma Patients Subgroup With Improved Median Overall Survival. Frontiers in Oncology, 10, 432.

Publication 2020

XN hematology analyzer

Complete blood count Hemoglobin Lymphocytes Mean corpuscular hemoglobin concentration Mean corpuscular volume Neutrophil Patients Rbcs Steroids Surgical

Corresponding Organization : Ben-Gurion University of the Negev

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Hemoglobin
RBCs count
Hematocrit (HCT)
Mean corpuscular hemoglobin (MCH)
Mean corpuscular hemoglobin concentration (MCHC)
Mean corpuscular volume (MCV)

control variables

Time points at which laboratory values were obtained (1-3 days prior to surgical intervention)
Patients treated with steroids following hospital admission

controls

Positive control: None mentioned
Negative control: None mentioned

Annotations

Based on most similar protocols

Obtain complete blood count (CBC) within 1-3 days prior to surgical intervention and automatically analyze using ADVIA 2120 hematology system or Sysmex XN hematology analyzer (Input protocol).

Examine pre-operative red blood cell (RBC) parameters including hemoglobin, RBC count, hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and red cell distribution width (RDW) (Input protocol).

Avoid analyzing white blood cell (WBC) differential and related calculated ratios (e.g., neutrophil-lymphocytes ratio) due to potential distortion by steroid treatment (Input protocol).

Obtain complete blood counts (WBC) weekly during chemoradiation, and define leukocytosis, neutrophilia, anemia, thrombocytosis, lymphopenia, and monocytosis based on specific thresholds (Protocol 1).

Calculate the neutrophil-lymphocyte ratio (NLR) using a cutoff of 4 for positivity, as per previous literature (Protocol 1).

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