Ocular and Metabolic Biomarkers Assessment

IOP was measured using Goldman applanation tonometry. Systolic blood pressure (SBP) and diastolic BP (DBP) were measured at baseline using an automatic BP monitor (UA-767, A&D Co. Ltd., Corby, UK) [30 (link)]. Ocular perfusion pressure (OPP) was then calculated as OPP = 2/3(2/3DBP + 1/3SBP)-IOP. Weight and height were recorded, and the body mass index (BMI) was calculated as: BMI = weight (kg)/height 2 (m). EDTA blood samples were obtained from the antecubital fossa vein and were tested immediately for fasting triglycerides (TGs), and total and HDL cholesterol (Total-C; HDL-C), using a Reflotron Desktop Analyser (Roche Diagnostics, Welwyn Garden City, UK). LDL cholesterol (LDL-C) was subsequently calculated as (Total-C) − (HDL-C) − (TG/5) [31 (link),32 (link)].

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Mroczkowska S., Shokr H., Benavente-Pérez A., Negi A., Bentham P, & Gherghel D. (2022). Retinal Microvascular Dysfunction Occurs Early and Similarly in Mild Alzheimer’s Disease and Primary-Open Angle Glaucoma Patients. Journal of Clinical Medicine, 11(22), 6702.

Publication 2022

Reflotron Desktop Analyser

Blood Body mass index Diagnostics Diastolic bp Edta Hdl cholesterol Ldl cholesterol Ocular Perfusion Pressure Systolic blood pressure Tonometry Triglycerides Vein

Corresponding Organization : University of Manchester

Other organizations : University Hospitals Birmingham NHS Foundation Trust

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Intraocular pressure (IOP) measured using Goldman applanation tonometry
Systolic blood pressure (SBP)
Diastolic blood pressure (DBP)
Ocular perfusion pressure (OPP) calculated as OPP = 2/3(2/3DBP + 1/3SBP)-IOP
Body mass index (BMI) calculated as BMI = weight (kg)/height 2 (m)
Fasting triglycerides (TGs)
Total cholesterol (Total-C)
HDL cholesterol (HDL-C)
LDL cholesterol (LDL-C) calculated as (Total-C) − (HDL-C) − (TG/5)

control variables

Measurements taken at baseline
EDTA blood samples obtained from the antecubital fossa vein
Blood samples tested immediately for fasting lipid profile

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