Operant Conditioning for Drug Delivery

Animals were tested in plexiglass operant chambers (Med Associates, St Albans, VT), equipped with two levers. The required number of responses at the reinforced (R) lever turned on a cue light over the lever, turned off the house light, and activated an externally mounted syringe pump that infused drug. During the infusion (5.6 s yielding 100 μl of solution) and timeout period (20 s) the cue light remained illuminated, and the house light remained off. After the timeout period, the house light turned on, the cue light is turned off and signaled the availability of a reinforcer. Responses on the non-reinforced (NR) lever were recorded but had no consequences. Procedures modeled previous work done in our lab (26 (link), 27 (link)).

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Gellner C.A., Carreño D., Belluzzi J.D, & Leslie F.M. (2023). Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats. Frontiers in Psychiatry, 14, 1096213.

Publication 2023

plexiglass operant chambers

Animals Drug Light Plexiglass Syringe

Corresponding Organization : University of California, Irvine

Top 5 similar protocols

Variable analysis

independent variables

Required number of responses at the reinforced (R) lever

dependent variables

Responses on the non-reinforced (NR) lever
Drug infusion

control variables

Plexiglass operant chambers (Med Associates, St Albans, VT), equipped with two levers
Cue light over the reinforced lever
House light
Externally mounted syringe pump that infused drug
Infusion duration (5.6 s yielding 100 μl of solution)
Timeout period (20 s)

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