Participants completed PET imaging [10 (link)] to determine amyloid burden using either Pittsburgh Compound B (PiB) or florbetapir (F-AV-45) radiotracers in a Siemens 962 HR+ECAT PET or Biograph 40 scanner (Siemens/CTI, Knoxville, KY). Amyloid burden was expressed in centiloids based on the mean cortical standardized uptake value ratio with partial volume correction via regional spread function [PIB MCSUVR RSF ≥ 16.4 and AV45 MCSUVR RSF ≥ 20.6] [11 (link)–13 (link)].
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PET Imaging of Amyloid Burden
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Corresponding Organization : Washington University in St. Louis
Other organizations : Center for Clinical Studies, Hope Center for Neurological Disorders
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Variable analysis
independent variables
- Type of radiotracer used for PET imaging (Pittsburgh Compound B (PiB) or florbetapir (F-AV-45))
- Amyloid burden expressed in centiloids based on the mean cortical standardized uptake value ratio with partial volume correction via regional spread function
- Siemens 962 HR+ECAT PET or Biograph 40 scanner (Siemens/CTI, Knoxville, KY) used for PET imaging
- Partial volume correction via regional spread function used to determine amyloid burden
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