Example 6

To investigate the effect of insulin on CNS signaling, LA1-55 neuroblastoma cells were treated for 1 hour with 200 nM of insulin. The results are shown in FIG. 6. The results can demonstrate that insulin treatment can increase Akt activity, Akt-dependent GSK3P and mTOR phosphorylation, aPKC activity and Aβ1-40/42 peptide levels in neuronal cells.

Additionally, activation of CNS p-Ser-473-Akt, p-Thr-55/560-aPKC, BACE1, aPKC activity and Aβ1-40/42 levels, by insulin in various mouse models was evaluated. Results are shown in FIGS. 5A-5B, FIGS. 7-8C.

Free full text: Click here