At each visit, a laboratory‐based HIV antigen/antibody test was performed at centralized laboratories in Zambia and South Africa. Additional testing was performed retrospectively at the HPTN Laboratory Center (Johns Hopkins Univ., Baltimore, MD, USA) [6 (link)], including confirmation of seroconversion events and determination of the timing of HIV acquisition. Viral load testing was performed using the RealTime HIV‐1 assay (Abbott Molecular; validated dilution method, limit of quantification: 400 copies/ml). Further details of laboratory testing are described elsewhere [6 (link)].
Skalland T., Ayles H., Bock P., Bwalya J., Shanaube K., Kasese N., Dupré M., Kosloff B., Floyd S., Wilson E., Moore A., Eshleman S., Fidler S., Hayes R, & Donnell D. (2023). Community‐ and individual‐level correlates of HIV incidence in HPTN 071 (PopART). Journal of the International AIDS Society, 26(8), e26155.
Antibody Antigen Assay Dilution method Hiv 1 Hiv test
Corresponding Organization : Fred Hutch Cancer Center
Other organizations :
Zambart, London School of Hygiene & Tropical Medicine, Desmond Tutu HIV Foundation, Stellenbosch University, Family Health International 360, Johns Hopkins Medicine, Johns Hopkins University, NIHR Imperial Biomedical Research Centre
Positive control: Seroconversion events were confirmed retrospectively at the HPTN Laboratory Center.
Negative control: Not mentioned
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