The UKB is composed of health-related information from ~500 000 individuals aged between 40 and 69 years recruited from across the United Kingdom from 2006 to 2010.16 (link) The patient registration process and GWAS data are described elsewhere.16 (link) Briefly, we used the genomic data based on genotyping either by the Applied Biosystems UK BiLEVE Axiom Array or by the Applied Biosystems UK Biobank Axiom Array and imputation using a combination of the Haplotype Reference Consortium, UK10K, and 1KG Phase 3 reference panels.17 (link) Variants imputed with Rsq >0.7 and a MAF >0.5% were used for the analysis. We included only individuals of British ancestry who passed QC (Method S2 ).
The definition of cases for PA was based on the International Classification of Diseases, Tenth Revision code of E26.0 (primary hyperaldosteronism). The cases for hypertension and controls were defined similarly to those in the Japanese cohort (Method S2 ). Eventually, we included 84 PA cases, 195 922 hypertension cases, and 180 314 controls in this study.
The definition of cases for PA was based on the International Classification of Diseases, Tenth Revision code of E26.0 (primary hyperaldosteronism). The cases for hypertension and controls were defined similarly to those in the Japanese cohort (
