The CNS Tumour Database search undertaken for our previously published cohort identified 67 patients with Grade 2 and 3 meningiomas resected at RMH/MPH and entered prospectively over 4 years. Of these, nine (16%) were excluded; six (9%) due to previous resections at other institutions or with destroyed records and three (4%) were lost to follow-up. Of the remaining 58 patients, 10 were identified who had tumours that had progressed in WHO Grade and had matched samples available for analysis.
Patient demographics (sex, date of birth, baseline Eastern Cooperative Oncology Group [ECOG] performance status), tumour characteristics (WHO grade, tumour location, radiology date), surgical details (type of surgery, extent of resection), and adjuvant therapy (chemotherapy, radiotherapy – date, dose and fractions) were collated. Extent of resection was designated as gross total resection (GTR, > 95%), subtotal resection (STR, 50–95%) or partial resection (PR, < 50%), as confirmed by both the surgeon’s impression at the time of surgery (100%) and first post-operative imaging (80% available).
Backfill of data allowed tumours to be included in the analysis that were previously resected as early as 1989. Central pathology review by an experienced neuropathologist was performed based on the WHO Classification, 2016 revision, to ensure consistency of grading. As a result of this review, one patient’s tumour was reclassified to Grade 2 from Grade 3.
Patient demographics (sex, date of birth, baseline Eastern Cooperative Oncology Group [ECOG] performance status), tumour characteristics (WHO grade, tumour location, radiology date), surgical details (type of surgery, extent of resection), and adjuvant therapy (chemotherapy, radiotherapy – date, dose and fractions) were collated. Extent of resection was designated as gross total resection (GTR, > 95%), subtotal resection (STR, 50–95%) or partial resection (PR, < 50%), as confirmed by both the surgeon’s impression at the time of surgery (100%) and first post-operative imaging (80% available).
Backfill of data allowed tumours to be included in the analysis that were previously resected as early as 1989. Central pathology review by an experienced neuropathologist was performed based on the WHO Classification, 2016 revision, to ensure consistency of grading. As a result of this review, one patient’s tumour was reclassified to Grade 2 from Grade 3.
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