Enrichment Analysis of Genetic Scores

Biological interpretation of genes that comprised our genetic score was performed using enrichment analysis using MetaCore^TM (Clarivate Analytics). The enrichment identifies statistically significant pathway maps and gene ontology processes associated with this list of genes after false discovery rate (FDR) correction, to summarize the most enriched and pertinent biology associated with the set of genes under investigation (Huang et al., 2009 (link)). We also performed enrichment analysis to identify genes differentially expressed at different developmental phases, via functional mapping of genetic and expression using the FUMA tool (Watanabe et al., 2017 (link)).

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de Mendonça Filho E.J., Barth B., Bandeira D.R., de Lima R.M., Arcego D.M., Dalmaz C., Pokhvisneva I., Sassi R.B., Hall G.B., Meaney M.J, & Silveira P.P. (2021). Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network. Frontiers in Neuroscience, 15, 744743.

Publication 2021

MetaCoreTM

Biological Gene processes Genes Genetic Maps

Corresponding Organization : McGill University

Other organizations : Universidade Federal do Rio Grande do Sul, University of British Columbia, McMaster University, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research

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Variable analysis

independent variables

Genetic score

dependent variables

Pathway maps
Gene ontology processes
Differentially expressed genes at different developmental phases

control variables

False discovery rate (FDR) correction

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