All experiments were performed in compliance with institutional guidelines and regulations following approval from the appropriate institutional review board (UCSF Office of Research Institutional Animal Care and Use Committee (IACUC), #AN185514-01). FVB mice (male, 4 weeks, weight ranged from 20-21gm) were obtained from Charles River (Charles River Laboratories, Wilmington, MA, RRID: IMSR_CRL:207) and nude mice (Foxn1nu, female, 4 weeks, weight ranged from 19-20gm) were obtained from the Jackson Laboratory (The Jackson Laboratory, Maine, RRID: IMSR_JAX:007850) and were maintained in accordance with the IACUC guidelines. Intracranial allografts were performed as described previously (24 (link)) (Supplemental Methods).