All the PI-RADS 3 lesions were biopsied transrectally by two experienced radiologists, who usually read at least 400 mpMRI per year, using the mpMRI-TRUS Fusion image guide feature of “Aplio™ 500 ultrasound system”, after antibiotic prophylaxis and a cleansing rectal enema, using a non-disposable biopsy gun (Medgun, Medax, Modena, Italy) with a disposable 18-gauge needle and a US platform (Canon-Toshiba Aplio 500™, Ōtawara, Kanto, Japan) with an end-fire TRUS probe as previously described (10 (link)).
The biopsy samples were analysed by two dedicated genitourinary pathologists who primarily identified the presence or absence of a neoplastic pathology on the samples. Each neoplastic lesion was graded from 1 to 5 according to the International Society of Urological Pathology (ISUP) Grade Group System (GGS) (12 (link)); lesions having a GGS ≥ 2 were considered to be clinically significant.
The biopsy samples were analysed by two dedicated genitourinary pathologists who primarily identified the presence or absence of a neoplastic pathology on the samples. Each neoplastic lesion was graded from 1 to 5 according to the International Society of Urological Pathology (ISUP) Grade Group System (GGS) (12 (link)); lesions having a GGS ≥ 2 were considered to be clinically significant.
Free full text: Click here
