The methods have been described previously.20 (link),21 (link) After an attenuation correction transmission scan, a bolus injection of [11C]PBR28 (n = 10) or [11C]DPA-713 (n = 1) was administered and dynamic PET images acquired for 90 minutes on an Advance scanner (GE Healthcare). Data were compared to 31 healthy volunteers. Metabolite-corrected arterial input functions were obtained during the [11C]PBR28 scans of 9 epilepsy patients (5 high affinity and 4 mixed affinity binders) and 11 age-matched healthy volunteers (5 high-affinity and 6 medium affinity). [11C]PBR28 plasma-free fraction (fP) was measured by ultrafiltration.
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Quantifying Neuroinflammation in Epilepsy
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Corresponding Organization : National Institute of Neurological Disorders and Stroke
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Variable analysis
independent variables
- Type of radioligand ([11C]PBR28 or [11C]DPA-713)
- Dynamic PET images acquired for 90 minutes
- [11C]PBR28 plasma-free fraction (f_P)
- Attenuation correction transmission scan
- Healthy volunteers (31 total)
- Epilepsy patients (9 total, 5 high affinity and 4 mixed affinity binders)
- Age-matched healthy volunteers (11 total, 5 high-affinity and 6 medium affinity)
- Positive control: Healthy volunteers
- Negative control: Not explicitly mentioned
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