Pharmacological Evaluation of Drug Interactions

Amodiaquine, diclofenac sodium, dextromethorphan, furafylline, tranylcypromine, ticlopidine, montelukast, sulfaphenazole, ketoconazole, omeprazole, atenolol, digoxin (European Pharmacopoeia reference standard), and verapamil were purchased from Sigma-Aldrich. Rifampicin and phenobarbital were purchased from Solarbio, China. Phenacetin, bupropion, flumazenil and minoxidil were purchased from the National Institutes for Food and Drug Control (NIDFC), China. Midazolam was procured from Cerilliant, TX, USA. Mephenytoin and N-3-benzylnirvanol were purchased from Toronto Research Chemicals (TRC), ON, Canada. Quinidine was procured from TCI, Japan. Testosterone (#A0256659, Acros) and acetonitrile were received from Fischer Scientific. ZB716 was synthesized as described in our earlier report [11 (link)].