The materials used in this research include Kelakai root extract, Tween 80 (Eralika-Indonesia), polyethylene glycol (PEG) 400 (Eralika-Indonesia), propylene glycol, methylparaben (Eralika-Indonesia), propylparaben (Eralika-Indonesia), Natrium carboxyl methylcellulose (Na-CMC) (Eralika-Indonesia), and virgin coconut oil (VCO) (Eralika-Indonesia). All reagents and solvents used were of analytical grade.