Automated Radiosynthesis of [11C]CH3I

[¹¹C]CH₄ was produced from a methane target via the ¹⁴N(p, α)¹¹C nuclear reaction in a cyclotron. The target was filled with nitrogen gas mixed with 10% hydrogen and bombarded for 2–5 min at 35 µA. [¹¹C]CH₃I was synthesized using the TracerMaker module with in-target-produced [¹¹C]CH₄ as previously reported [30 (link)]. After the production of [¹¹C]CH₃I (~3–5.5 GBq), it was transferred through a separate line directly connected to the iMiDEV™ radiosynthesizer. The flow rate of [¹¹C]CH₃I was set at 8 mL/min [24 (link)].

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Mallapura H., Tanguy L., Mahfuz S., Bylund L., Långström B., Halldin C, & Nag S. (2024). Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[11C]Methionine and [11C]Choline. Pharmaceuticals, 17(2), 250.

Publication 2024

Corresponding Organization :

Other organizations : Stockholm County Council, Karolinska Institutet, Alcen (France), Karolinska University Hospital, Uppsala University

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Variable analysis

independent variables

Bombardment time (2-5 min)
Beam current (35 μA)

dependent variables

Production of [11C]CH4
Synthesis of [11C]CH3I
Activity of [11C]CH3I (3-5.5 GBq)
Flow rate of [11C]CH3I (8 mL/min)

control variables

Nitrogen gas mixed with 10% hydrogen as the target material
Use of TracerMaker module for [11C]CH3I synthesis
Use of iMiDEV™ radiosynthesizer for [11C]CH3I transfer

controls

No positive or negative controls were explicitly mentioned.

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