Preparation of Telmisartan-Maleic Acid Cocrystals

Telmisartan-maleic acid cocrystals were prepared using different stoichiometric amounts of telmisartan and maleic acid (Table 1). The molar ratios of the pure drug as well as the coformer were varied to observe the impact of drug:coformer ratio on crystallization. The specific molar ratio of telmisartan (514 mg, 1 mmoL) and maleic acid (116 mg, 1 mmoL) was mixed physically using an ointment slab. Then the drug-coformer powder blend was slowly added to a solvent mixture (i.e., distilled water: ethanol; 1:1) and stirred continuously, using a magnetic stirrer until the ethanol was evaporated out. Then it was transferred into a petri dish and kept at 50 °C for complete drying. Finally, the formed crystalline material was scrapped and stored in a desiccator for further use.