Multimodal MRI Acquisition and Preprocessing

Procedures for image acquisition and pre-processing have been performed by UK Biobank, and are available on the UK Biobank website (http://www.ukbiobank.ac.uk/), and have been documented previously33 37 (link). In short, images were collected in Cheadle Manchester on a Siemens Skyra 3.0 T scanner (Siemens Medical Solutions, Germany) with a 32-channel head coil (https://www.healthcare.siemens.com/magnetic-resonance-imaging). T1-weighted scans were acquired using a 3D MPRAGE (resolution 1 mm³ isotropic voxels) sequence, and diffusion-weighted (DW) scans were acquired with a monopolar Steejskal-Tanner pulse sequence and multi-shell acquisition (b₀ = 0 s/mm², b = 1,000 s/mm², b = 2,000 s/mm²). Images were preprocessed and analysed with the FMRIB Software Library (FSL) (http://fsl.fmrib.ox.ac.uk/fsl). More detailed information is reported in the supplementary materials.

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Reus L.M., Shen X., Gibson J., Wigmore E., Ligthart L., Adams M.J., Davies G., Cox S.R., Hagenaars S.P., Bastin M.E., Deary I.J., Whalley H.C, & McIntosh A.M. (2017). Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank. Scientific Reports, 7, 42140.

Publication 2017

Skyra 3.0 T scanner 32-channel head coil

Diffusion Head Library Scans

Corresponding Organization : University of Edinburgh

Other organizations : Vrije Universiteit Amsterdam

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

None explicitly mentioned

control variables

Procedures for image acquisition and pre-processing performed by UK Biobank
Images collected on a Siemens Skyra 3.0 T scanner with a 32-channel head coil
T1-weighted scans acquired using a 3D MPRAGE sequence
Diffusion-weighted (DW) scans acquired with a monopolar Steejskal-Tanner pulse sequence and multi-shell acquisition (b0 = 0 s/mm2, b = 1,000 s/mm2, b = 2,000 s/mm2)
Images preprocessed and analysed with the FMRIB Software Library (FSL)

controls

Positive control: None mentioned
Negative control: None mentioned

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