PET Imaging of Amyloid Deposition

PET images were obtained on a GE Discovery ST-16 PET/CT Scanner. Two 5-min PET brain frames were acquired continuously, approximately 50 min after [18F] florbetapir (370 MBq) administration. Self-adherent wrap across the forehead was used to minimize head movement. Frames were summed, and attenuation corrected. To increase tissue uptake specificity, we calculated standardized uptake value ratios (SUVR) in several individualized regions using a custom processing pipeline in SPM12 (http://www.fil.ion.ucl.ac.uk/spm) as described previously [23 (link)].

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Kaufman C.S., Vidoni E.D., Burns J.M., Alwatban M.R, & Billinger S.A. (2020). Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults. Nutrients, 12(3), 697.

Publication 2020

Discovery ST-16 PET/CT Scanner

Brain Florbetapir Forehead Frames Head movement Pet ct Tissue specificity

Corresponding Organization : University of Kansas Medical Center

Other organizations : University of Kansas

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Variable analysis

independent variables

Administration of [18F] florbetapir (370 MBq)

dependent variables

Standardized uptake value ratios (SUVR) in several individualized regions

control variables

Self-adherent wrap across the forehead to minimize head movement
Custom processing pipeline in SPM12 to increase tissue uptake specificity

controls

No positive or negative controls were explicitly mentioned in the input.

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