Standardized Assessment of C. jejuni Infection

To assess clinical signs of C. jejuni induced infection on a daily basis, a standardized cumulative clinical score (maximum 12 points, addressing the occurrence of blood in feces (0 points: no blood; 2 points: microscopic detection of blood using Haemoccult, Beckman Coulter / PCD, Krefeld, Germany; 4 points: overt blood visible), diarrhea (0: formed feces; 2: pasty feces; 4: liquid feces), and the clinical aspect (0: normal; 2: ruffled fur, less locomotion; 4: isolation, severely compromised locomotion, pre-final aspect) was used (Haag et al., 2012a (link),b (link)).

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Heimesaat M.M., Alutis M., Grundmann U., Fischer A., Tegtmeyer N., Böhm M., Kühl A.A., Göbel U.B., Backert S, & Bereswill S. (2014). The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice. Frontiers in Cellular and Infection Microbiology, 4, 77.

Publication 2014

Haemoccult

Blood Diarrhea Feces Haag Haemoccult Infection Isolation Locomotion Microscopic

Corresponding Organization :

Other organizations : Charité - Universitätsmedizin Berlin, Friedrich-Alexander-Universität Erlangen-Nürnberg

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Occurrence of blood in feces (0 points: no blood; 2 points: microscopic detection of blood using Haemoccult; 4 points: overt blood visible)
Diarrhea (0: formed feces; 2: pasty feces; 4: liquid feces)
Clinical aspect (0: normal; 2: ruffled fur, less locomotion; 4: isolation, severely compromised locomotion, pre-final aspect)

control variables

None explicitly mentioned

controls

No positive or negative controls were explicitly mentioned in the information provided.

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