Nationwide Children’s Hospital (NCH) is a referral center for evaluation and management of CD in the US. Since July of 2014, patients with differential diagnosis of CD have undergone tTG testing using QUANTA Flash® chemiluminescence assay (INOVA Diagnostics, Inc., San Diego, CA) which has extended analytical range (see Additional file 1) and superior performance for CD [63 (link)–65 (link)]. In addition, all duodenal biopsies at NCH are evaluated by experience pathologists and subject to clinicopathological consensus review.
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