Systematic Literature Review of Oncogenes and Tumor Suppressors

We systematically searched the existing literature for any evidence for a potential tissue-specific role as oncogenes or TSGs in the target genes of the detected regulatory driver candidates in solid cancers. For the search, we used the combination of the gene symbol (also checking for alternative/previous gene or protein names), and the cancer type (e.g. lung cancer, lung adenocarcinoma, brain cancer, medulloblastoma, etc.) on PubMed.gov, MalaCards.org (27 (link)), and Google Scholar. The following observations were considered strong evidence of being an oncogene or a TSG: experimental studies directly showing a promoting or protecting effect on tumour formation, proliferation, apoptosis, metastases etc. or use of the gene as a drug target in ongoing or published clinical studies. The following observations were considered weak evidence: studies claiming the oncogenic/TSG role based on combined indirect evidence, such as increased/decreased expression compared to neighbouring normal tissue, prognostic effect and computational/in silico studies, usually supported also by experimental evidence in other tissues. The evidence considered for each individual gene is listed in Supplementary Table S3.