CONSTRUCT Trial Health Service Costs

The decision models are based on healthcare services use and costs captured in the CONSTRUCT trial. NHS resource use were collected from case report forms (CRFs) and participant follow-up questionnaires (PFQs) completed at each follow-up time points, supplemented by post-colectomy questionnaire, SAE forms and relevant data provided by participating sites. The costs of all healthcare services use were estimated using standard NHS Pay and Price index. These included trial drugs, their preparation and administration costs, NHS contacts, consultant (clinic visit, telephone call, dietician), primary care general practitioner (at practice, home visit, telephone call), health visitor, nurse specialist, tests and investigations, hospitalizations (with and without surgery), readmissions, etc. Details on NHS resource uses, how these were captured and their costs (in 2012–13 prices in Great Britain Pound (GBP) sterling) were reported in the CONSTRUCT main report [22 ] hence not repeated in the manuscript, however, in this study an adjustment was made by using consumer price index (CPI) to inflate these costs to the year 2019 [31 (link)]. The unit costs of the two trial drugs are given in Appendix 5.