Protocol detail

Prepregnancy Health Impacts on Complications

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To estimate the effect of general health prior to pregnancy on the risk of pre-pregnancy complications, six categories were created based on reported medical history: (i) Gynecological history (diagnosed or suspected endometriosis or PCOS), (ii) Non-gastrointestinal chronic inflammatory diseases (diagnosed rheumatoid arthritis, autoimmune diseases or multiple sclerosis (MS)), (iii) Gastrointestinal problems (gastric acid medication, diagnosed Crohn’s disease or ulcerative colitis), (iv) Mental health (eating disorder, anti-depressive-, anti-anxiety- or sleeping medication), (v) Chronic respiratory diseases and allergies (asthma, hay fever, allergies, asthma- or allergy medication) and (vi) Endocrine indications (thyroid medication or diagnosed hypothyroidism). These categories were not mutually exclusive. Participants with each comorbidity were compared to those without the specific comorbidity; and the group with any of these comorbidities was also compared to those without.

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Gudnadottir U., Du J., Hugerth L.W., Engstrand L., Schuppe-Koistinen I., Wiberg Itzel E., Fransson E, & Brusselaers N. (2023). Pre-pregnancy complications - associated factors and wellbeing in early pregnancy: a Swedish cohort study. BMC Pregnancy and Childbirth, 23, 153.

Publication 2023

Allergies Allergy medication Anxiety Asthma Autoimmune diseases Complications of pregnancy Crohn s disease Eating disorder Endocrine Endometriosis Gastric acid Gastrointestinal diseases Hay fever Hypothyroidism Inflammatory Medication Mental health Multiple sclerosis Pcos Respiratory diseases Rheumatoid arthritis Thyroid Ulcerative colitis

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Variable analysis

independent variables

Gynecological history (diagnosed or suspected endometriosis or PCOS)
Non-gastrointestinal chronic inflammatory diseases (diagnosed rheumatoid arthritis, autoimmune diseases or multiple sclerosis (MS))
Gastrointestinal problems (gastric acid medication, diagnosed Crohn's disease or ulcerative colitis)
Mental health (eating disorder, anti-depressive-, anti-anxiety- or sleeping medication)
Chronic respiratory diseases and allergies (asthma, hay fever, allergies, asthma- or allergy medication)
Endocrine indications (thyroid medication or diagnosed hypothyroidism)

dependent variables

Risk of pre-pregnancy complications

control variables

Not explicitly mentioned

controls

Participants with each comorbidity were compared to those without the specific comorbidity
The group with any of these comorbidities was also compared to those without

Annotations

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