Integrative Analysis of Sorafenib-Resistant Liver Cancer

The two datasets, sorafenib-resistant dataset for Huh7 cells (GSE94550, [9 (link)]) and the Roessler Liver microarray dataset (GSE14520, [10 (link)]) were retrieved, and utilized > 2-fold change as the criterion for selection of sorafenib-modulated molecules in sorafenib-resistant Huh7 cells compared to parental cells (GSE94550) and > 1.2-fold as the criterion for choosing oncogenes related to survival in the bottom 25% vs. the top 25% of HCC patients from the Roessler Liver microarray dataset (GSE14520) to intersect the potential candidates.

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Tsai H.W., Chen Y.L., Wang C.I., Hsieh C., Lin Y.H., Chu P.M., Wu Y.H., Huang Y.C, & Chen C.Y. (2023). Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma. Cancer Cell International, 23, 42.

Publication 2023

Cells Liver Microarray Oncogenes Parental Patients Sorafenib

Corresponding Organization :

Other organizations : National Cheng Kung University Hospital, National Cheng Kung University, China Medical University, Chiayi Chang Gung Memorial Hospital, Chang Gung Memorial Hospital, Chung Shan Medical University

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Variable analysis

independent variables

Sorafenib treatment
Comparison of sorafenib-resistant Huh7 cells to parental Huh7 cells
Comparison of HCC patients with bottom 25% survival to those with top 25% survival

dependent variables

Sorafenib-modulated molecules in sorafenib-resistant Huh7 cells
Oncogenes related to survival in HCC patients

control variables

Not explicitly mentioned

controls

Not specified

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