DNA methylation data from whole blood samples were assessed using an Infinium MethylationEPIC BeadChip microarray (Illumina Inc., San Diego, California) according to the manufacturer’s protocol for the discovery, first, and second replication cohorts (NIAAA and GS). The third replication sample (GTP) and neural tissues from both postmortem cohorts were assessed with the Illumina 450K chip as described previously [37 (link), 38 (link)]. Pre-processing of the GS data has been described in detail elsewhere [39 (link)].
Lohoff F.W., Roy A., Jung J., Longley M., Rosoff D.B., Luo A., O’Connell E., Sorcher J.L., Sun H., Schwandt M., Hodgkinson C.A., Goldman D., Momenan R., McIntosh A.M., Adams M.J., Walker R.M., Evans K.L., Porteous D., Smith A.K., Lee J., Muench C., Charlet K., Clarke T.K, & Kaminsky Z.A. (2020). Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation. Molecular Psychiatry, 26(6), 2224-2237.
Corresponding Organization : National Institutes of Health
Other organizations :
Royal Ottawa Mental Health Centre, University of Ottawa, University of Edinburgh, MRC Institute of Genetics and Molecular Medicine, Medical Research Council, Emory University
Infinium MethylationEPIC BeadChip microarray (Illumina Inc., San Diego, California)
Illumina 450K chip
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