Throughout the study period, MRI of the brain was performed on the same 1.5T scanner (General Electric Healthcare, Milwaukee, WI) using an 8‐channel head coil. Imaging acquisition included a high‐resolution, three‐dimensional (3D) T1‐weighted, proton density weighted and a fluid‐attenuated inversion recovery (FLAIR) sequence. A detailed protocol of the Rotterdam Scan Study is described elsewhere.
31 (link) Volumes in milliliters (mL) of the total brain, gray matter, and white matter was obtained by automated tissue segmentation based on a k‐nearest neighbor algorithm. All segmentations were visually inspected and manually corrected when necessary. Volumes of the hippocampus, thalamus, and amygdala were obtained by processing T1‐weighted images with FreeSurfer (version 6.0).
32 (link)
31 (link) Volumes in milliliters (mL) of the total brain, gray matter, and white matter was obtained by automated tissue segmentation based on a k‐nearest neighbor algorithm. All segmentations were visually inspected and manually corrected when necessary. Volumes of the hippocampus, thalamus, and amygdala were obtained by processing T1‐weighted images with FreeSurfer (version 6.0).
32 (link)
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