FDG PET/CT Quantitative Metrics for Liver Metastases

MTV was obtained from all liver metastases by manually placing a volume of interest (VOI) over each metastasis using a Siemens SyngoVia workstation (version VB10A, Erlangen, Germany) and a fixed threshold of 40%. MTV was only registered if the uptake was higher than the mean liver background uptake × 1.5 + standard deviation of the liver background × 2 [17 (link)]. Patients without any metastases with uptake above this value were given an MTV value of zero. Liver background was measured by placing a VOI of 3 cm in the right liver lobe. Total MTV was calculated by adding the values from all metastases for each patient. Maximum standardized uptake value (SUV_max), SUV_mean, SUV_peak, tumor to background (T/B) ratio and total lesion glycolysis (TLG) were also registered. In patients with more than one liver metastasis the highest SUV was registered. SUV_peak was defined as the SUV_mean of the volume of 1 cm³ around the SUV_max. TLG was calculated by multiplying SUV_mean by MTV.

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Grut H., Line P.D., Syversveen T, & Dueland S. (2022). Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study. Annals of Nuclear Medicine, 36(12), 1073-1081.

Publication 2022

SyngoVia workstation

Glycolysis Liver Metastasis Patients Tumor

Corresponding Organization : Vestre Viken Hospital Trust

Other organizations : University of Oslo, Oslo University Hospital

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Variable analysis

independent variables

Manually placing a volume of interest (VOI) over each metastasis using a Siemens SyngoVia workstation (version VB10A, Erlangen, Germany) and a fixed threshold of 40%

dependent variables

Metabolic tumor volume (MTV)
Maximum standardized uptake value (SUVmax)
SUVmean
SUVpeak
Tumor to background (T/B) ratio
Total lesion glycolysis (TLG)

control variables

Liver background was measured by placing a VOI of 3 cm in the right liver lobe

controls

Patients without any metastases with uptake above the threshold value were given an MTV value of zero

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