Celecoxib Solubility Enhancement via Polymer Blends

Polyvinyl alcohol (PVA, Parteck MXP^®) was kindly donated by Merck (Darmstadt, Germany). HPMCAS LG (hydroxypropylmethylcellulose acetate succinate) was provided by Shin-Etsu Chemical (Tokyo, Japan). Copovidone, Kolliphor P188 and Kolliphor P407 were donated by BASF (Ludwigshafen, Germany). HPC-SSL was obtained from Nisso Chemical Europe (Düsseldorf, Germany) and Eudragit L100-55 was obtained from Evonik (Darmstadt, Germany). Celecoxib (CXB) was obtained from Swapnroop Drugs & Pharmaceuticals (Aurangabad, India) (Figure 1). Lecithin and sodium taurocholate were purchased from Alfa Aesar (Haverhill, MA, USA). FaSSIF-V2 medium was prepared according to Denninger et al. [30 (link)], in henceforth will be referred to as FaSSIF.