Gadolinium(III) (1,4,7,10-tetraazacyclododecane)-1,4,7,10-tetraacetate (Gd-DOTA) was purchased from Marcocylics (Dallas, TX). 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycerol)-2000] ammonium salt (DSPE-PEG2000) was purchased from Avanti Polar Lipids, Inc. (Alabaster, AL). Doxorubicin hydrochloride (DOX) was from Sigma (St. Louis, MO). Sodium Acetate-d3, D2O(99.9% atom %D), 3-(Trimethylsilyl) propionic-2,2,3,3,-d4 sodium (TSP) and 3-(Trimethylsilyl)-1-propanesulfonic sodium (DSS) were purchased from Aldrich (St. Louis, MO). The water used in this work was generated from Milli-Q system (Millipore Corporation, Danvers, MA).
Protocol detail
Gd-DOTA Nanoparticle Synthesis and Characterization
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Alabaster
Ammonium salt
Doxorubicin hydrochloride
Dspe peg2000
Gadolinium
Gd dota
Glycerol
Lipids
Phosphoethanolamine
Polyethylene
Sodium
Sodium acetate
Corresponding Organization :
Other organizations : City Of Hope National Medical Center
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Variable analysis
independent variables
- Gadolinium(III) (1,4,7,10-tetraazacyclododecane)-1,4,7,10-tetraacetate (Gd-DOTA)
- 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycerol)-2000] ammonium salt (DSPE-PEG2000)
- Doxorubicin hydrochloride (DOX)
- Not explicitly mentioned
- Sodium Acetate-d3
- D2O (99.9% atom %D)
- 3-(Trimethylsilyl) propionic-2,2,3,3,-d4 sodium (TSP)
- 3-(Trimethylsilyl)-1-propanesulfonic sodium (DSS)
- Water generated from Milli-Q system (Millipore Corporation, Danvers, MA)
- Not explicitly mentioned
- Not explicitly mentioned
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