All of the patients underwent PET/CT using a dedicated PET/CT system (United Imaging, uMI780, China) at 60 ± 5 min after intravenous injection of 2–2.3 MBq/kg 68Ga-PSMA-11 synthesized as previously described (17 (link)). A nonenhanced CT scan (120 kV, mA modulation, pitch 0.988, slice thickness 3.0 mm, increment 1.5 mm) was obtained, followed by a whole-body PET scan (3 min/bed, field of view 60 cm) in 3D mode (matrix 256 × 256) from the vertex to the proximal legs. The datasets were fully corrected for random coincidences, scatter radiation, and attenuation. For PET image reconstruction, the ordered-subsets expectation maximization method was used. Attenuation corrections of the PET images were performed using data from the CT scans. PET/CT fusion was performed using a workstation (uWS-MI, United Imaging).
The volumes of interest (VOIs) for the prostate gland were accurately delineated and segmented slice by slice using 3D Slicer software (version: 4.1.1.0;www.slicer.org ) by a highly experienced nuclear medicine radiologist (FW) with 20 years of expertise in prostate PET/CT. The radiologist, blinded to the clinical information, performed this task by carefully analyzing the PET images and factoring in the corresponding CT scan for accurate localization and segmentation of the VOIs.
The volumes of interest (VOIs) for the prostate gland were accurately delineated and segmented slice by slice using 3D Slicer software (version: 4.1.1.0;
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