Anal Fistula and Diabetes Retrospective

This clinical retrospective study collected 408 cases of anal fistula combined with T2DM attending the Hospital of Chengdu University of Chinese Medicine from June 2017 to May 2022. The study excluded anal fistula caused by Crohn's disease or exotic injuries (from indigestible diets or external devices). Extremely complicated fistulas that were not suitable for fistulotomy, cutting seton surgery or a combination procedure were screened out. And fistulas in the active phase of anal fistula were excluded. Research recruited 408 patients, but 43 patients were eliminated because of recurrence (within 6 months) (n = 35), severe clinical data deficits, failure to perform surgery, or missed visits. In the end, a total of 365 patients were included. Up on wound recovery time, patients were divided into the non-healing (refractory) group (n = 170) and the healing group (n = 195), respectively. After matching, there were 122 patients in each group. The detailed operation procedure was shown in Figure 1. This study was approved by the ethics committee of the Hospital of Chengdu University of Traditional Chinese Medicine (ethics number: 2022KL-018). The research was a retrospective clinical study and only the patients’ previous treatment data were extracted through the medical system. Therefore, no informed consent was required from the patients.

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Tang X., He T., Li X., Liu Y., Wu Y., You G., Li J., Yun Y., Wu L., Li L, & Kang J. (2023). Clinical features and independent predictors of postoperative refractory trauma to anal fistula combined with T2DM: A propensity score-matched analysis-retrospective cohort study. Frontiers in Surgery, 10, 1119113.

Publication 2023

Anal fistulas Chinese Crohn Devices Diets Fistulas Hospital ethics committee Injuries Medicine Patients Recurrence Wound

Corresponding Organization :

Other organizations : Chengdu University of Traditional Chinese Medicine

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Variable analysis

independent variables

Anal fistula combined with T2DM

dependent variables

Wound recovery time
Healing group
Non-healing (refractory) group

control variables

Anal fistula caused by Crohn's disease or exotic injuries (from indigestible diets or external devices)
Extremely complicated fistulas that were not suitable for fistulotomy, cutting seton surgery or a combination procedure
Fistulas in the active phase of anal fistula

controls

Positive controls: Not specified
Negative controls: Not specified

Annotations

Based on most similar protocols

The protocols use C57BL/6 or C57BL/6J male mice, which are commonly used animal models for studying NAFLD/NASH (Protocols 1-5).

The mice are typically maintained under standard housing conditions with a 10-12 h light/dark cycle and controlled temperature (Protocols 1-5).

The protocols use various dietary interventions to induce NAFLD/NASH, including high-fat diet (HFD), western diet (WD), and high-sugar solutions containing fructose and glucose (Protocols 1-5).

Some protocols also include administration of carbon tetrachloride (CCl4) to further exacerbate liver injury (Protocols 1, 4, and 5).

The protocols employ randomization to assign mice into control and experimental groups (Protocols 1-5).

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