Metabolic Intervention in Dio Mice
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Corresponding Organization :
Other organizations : Sun Yat-sen University
Variable analysis
- HDAC3 inhibitor dose (10 μg/kg body weight/day)
- Pioglitazone dose (10 mg/kg body weight/day)
- Blood glucose levels
- Fourteen-week-old Dio mice
- High-fat diet (D12492) for 8 weeks prior to experiment
- Quarantine period after purchase
- Intraperitoneal injection of insulin (0.75 unit/kg of body weight) after 4-h fast
- Blood glucose monitoring using FreeStyle blood glucose monitoring system
- Positive control: Pioglitazone group
- Negative control: PBS with 0.1% DMSO group
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