FDG-PET Imaging of Cerebral Glucose Metabolism

Siemens Inveon PET was used in this study [21 (link)]. Regional cerebral glucose metabolism was measured using ¹⁸F-fluorodeoxyglucose (FDG) PET. Before PET scanning, mice (n = 10 per group, female) fasted for at least 8 h, after which they were anesthetized with 2% isoflurane in 100% oxygen (Forane solution, Choongwae Pharma, Seoul, Korea). During PET scanning, the body temperature was maintained at 36 °C with heating pads. Then, 200 μCi of ¹⁸F-FDG was injected through a tail vein. After 30 min of uptake, 30-min emission PET data were acquired with an energy window of 350–650 keV. Emission list-mode data were sorted into three-dimensional (3D) sinograms and reconstructed using 3D reprojection algorithms. No filter was applied. The image matrix measured 256 × 256 × 159, the pixel size was 0.155 × 0.155 mm², and the slice thickness was 0.796 mm.

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Lee S., Lee H.J., Kang H., Kim E.H., Lim Y.C., Park H., Lim S.M., Lee Y.J., Kim J.M, & Kim J.S. (2019). Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect. Journal of Clinical Medicine, 8(2), 234.

Publication 2019

Inveon PET

18f fluorodeoxyglucose Body temperature Female Glucose Isoflurane Metabolism Mice Oxygen Tail Vein

Corresponding Organization : Korea University of Science and Technology

Other organizations : Korea University

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Variable analysis

independent variables

Fasting duration (at least 8 h)

dependent variables

Regional cerebral glucose metabolism

control variables

Mouse strain (female)
Anesthesia (2% isoflurane in 100% oxygen)
Body temperature (maintained at 36 °C)
PET scanning parameters (energy window, reconstruction algorithms, image matrix, pixel size, slice thickness)

controls

No explicit mention of positive or negative controls

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